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Vitamin B12 deficiency can lead to the production of large-sized RBC with functional defects leading to megaloblastic anaemia. Vitamin B12 is also required to maintain the central nervous system and its deficiency can lead to neurological deficits.
Despite adequate dietary intake intrinsic factor deficiency or parietal cell antibody can lead to vitamin B12 deficiency. Establishing the cause of Vitamin B12 is essential for treatment.

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