For years the rapid growth of antibiotic-resistant pathogens has severely jeopardized the health condition of human beings, yet the spread of such a threat continues to increase and has brought catastrophic consequences. Microbial pathogens have developed resistance mechanisms including: (i) decreased uptake and increased efflux of the drug through transmembrane efflux pumps; (ii) genetic alteration of the antibiotic targets with reduced affinity compared to the unaltered targets, (iii) production of enzymes which covalently modify or degrade the key structural motifs important for activity; and (iv) modification of membrane charge or sterol structure/composition. https://www.cd-bioparticles.ne....t/antimicrobial-lipi