Vardenafil, the active component in Zhewitra, works by inhibiting the enzyme phosphodiesterase type 5 (PDE5). This enzyme is responsible for breaking down cyclic guanosine monophosphate (cGMP), a molecule that helps relax the smooth muscles in the blood vessels of the penis. By inhibiting PDE5, Zhewitra increases the levels of cGMP, promoting blood flow to the penis when sexually stimulated, which helps achieve an erection.

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