Penegra 50 mg works by blocking the enzyme phosphodiesterase type 5 (PDE5). During sexual arousal, nitric oxide is released in penile tissue, increasing levels of cyclic guanosine monophosphate (cGMP). This chemical relaxes smooth muscles in blood vessels and allows increased blood flow into the penis. Sildenafil helps maintain these effects by preventing the breakdown of cGMP. Penegra 50 mg should not be taken with nitrate medicines used for chest pain, as this combination can cause a dangerous drop in blood pressure.
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