Dosage and duration: Taking a low dose (e.g., 200mg) for a brief time (e.g, one-time use) might be okay on an empty stomach. However, higher doses or extended use increase the risk of belly problems. Age (over sixty-five), history of stomach ulcers, bleeding problems, certain clinical conditions, and concurrent use of other medications like steroids or blood thinners can significantly increase the hazard of belly problems with ibuprofen on empty stomach, irrespective of whether you're taking it with meals.
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