Premenstrual Dysphoric Disorder (PMDD) is a much more severe form of premenstrual syndrome (PMS). It may affect women who can get pregnant. PMDD causes severe irritability depression or anxiety a week or two before your period starts. Premenstrual Dysphoric Disorder Symptoms usually go away two to three days after your period begins. PMDD is typically diagnosed after careful tracking of symptoms over several menstrual cycles. Treatment options include medication, psychotherapy, and self-help and coping strategies. Fluoxetine is one medication that is commonly used to treat PMDD.