Take Vigora 50 mg approximately 30 minutes to 1 hour before anticipated sexual activity. This allows the medication sufficient time to be absorbed and take effect. While Vigora 50 mg can be taken with or without food, taking it on an empty stomach may help it be absorbed more quickly. Consuming alcohol or grapefruit juice while taking Vigora 50 mg may increase the risk of side effects. It's advisable to limit or avoid these substances during the medication period.