Hepatitis A is a self-limited disease and chronic stage or other complications are rare. Infections occur early in life in areas with poor sanitation and crowded living conditions. With improved sanitation and hygiene, infections are delayed and consequently the number of persons susceptible to the disease increases. Because the disease is transmitted through the fecal-oral route, in dense populated regions an outbreak can arise from single contaminated source. The Hepatitis virus (HAV) is a Picornavirus; it is non-enveloped and contains a single-stranded RNA packaged in a protein shell. HAV has four major, structural polypeptides (VP1-4; 60 copies of VP1, 30-33 kD; VP2, 24-30 kD; VP3 (21-28 kD) and it localizes exclusively in the cytoplasm of human hepatocytes. The infection with HAV induces strong immunological response and elevated levels first of IgM and then IgG are detectable within a few days after the onset of the symptoms. IgG is an indicator of past infection and immunity to HAV. HAV is detected by the presence of HAV antigens or antibodies using ELISA. HAV occurs endemically in all parts of the world. https://www.creative-diagnosti....cs.com/human-anti-he
