Tazzle should not be used by individuals taking nitrates (commonly prescribed for chest pain) or guanylate cyclase stimulators (for pulmonary hypertension), as this can cause a significant drop in blood pressure. Tadalafil works by inhibiting the enzyme phosphodiesterase type 5 (PDE5), which breaks down cyclic guanosine monophosphate (cGMP) in the corpus cavernosum of the penis. By blocking PDE5, tadalafil increases the levels of cGMP. This causes relaxation of the smooth muscle in the blood vessels of the corpus cavernosum. The relaxation of these muscles allows for increased blood flow into the penis, which helps achieve and maintain an erection during sexual stimulation.

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