Vidalista is available in multiple strengths, including 2.5 mg, 5 mg, 10 mg, and 20 mg, allowing doctors to tailor the dose to individual needs. It is usually taken 30–60 minutes before sexual activity, though some lower-dose formulations can be used daily for more spontaneous sexual activity. Effects can last up to 36 hours, giving men a longer window for sexual engagement compared to other ED medications. During sexual arousal, nitric oxide is released in the penile tissue, stimulating the production of cyclic GMP (cGMP). cGMP relaxes the smooth muscles and dilates blood vessels, allowing increased blood flow into the penis.

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