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THE PHARMACEUTICAL INDUSTRY IS PRESENTLY EXPERIENCING A PROMINENT NEED FOR BIOAVAILABILITY ENHANCEMENT TECHNOLOGIES AND SERVICES

Over the last couple of decades, the concept of bioavailability has garnered significant attention in the pharmaceutical industry. It is considered to be one of the most important pharmacokinetic properties of a drug.

Bioavailability refers to the proportion of a drug that reaches systemic circulation unaltered, post dose administration. Additionally, it is a direct consequence of the absorption potential of an active pharmaceutical ingredient (API). The bioavailability of a drug is dependent on several factors, such as solubility, route of administration and metabolism of the drug post administration. The following figure provides different factors that have been reported to impact drug bioavailability either directly or indirectly. For this purpose, substantial mergers and acquisitions have been reported in this market, as service providers strive to become one-stop-shops, to cater to the diverse needs for their clientele. In addition, several stakeholders are engaged in the development of proprietary technologies, based on sustained release principle and bioavailability enhancers, to maintain a competitive edge in this rapidly emerging market. An increasing number of drug candidates have been granted approval via the 505(b)(2) pathway; the aforementioned pathway is used to gain approval for novel formulations consisting of previously approved active pharmaceutical ingredient (API). Additionally, given the shifting focus of drug developers towards development of lipophilic drug compounds, the industry is actively undertaking efforts to identify various bioavailability enhancement techniques, in order to mitigate the challenge of low bioavailability and stability.

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 Solubility: The solubility of a substance refers to its ability to dissolve in a solvent and form a homogeneous system. Drug solubility is considered to be one of the most important factors responsible for enabling a therapeutic intervention to be efficiently distributed via systemic circulation. It is worth highlighting that a drug’s solubility is directly proportional to its bioavailability and hence, is one of the primary parameters that is modified during bioavailability enhancement
 Permeability: Permeability refers to the ability of a molecule to pass through biological membranes. Similar to solubility, drug permeability plays a key role in its absorption and systemic distribution. Membrane based efflux mechanisms and other structural barriers are the major biological elements responsible for poor permeability of drugs. Permeability of a drug is also proportional to its bioavailability; however, it is possible to improve this characteristic by modifying the physiochemical properties of the drug to render them more suitable for absorption across different types of biological membranes.
 Molecule Size: Rate of absorption increases inversely with the size of a drug molecule. However, several studies have demonstrated that, absorption mechanisms vary significantly for different sizes of molecules. For instance, larger molecules get absorbed either by endocytosis or facilitated diffusion, whereas smaller molecules are absorbed via aqueous diffusion or through lipid channels.
 Degree of Ionization: Degree of ionization has a direct impact on drug absorption. Higher degree of ionization of a drug molecule results in poor solubility. As a general rule, basic drugs get ionized in acidic medium and are therefore, poorly soluble in acidic medium. The same rule applies to acidic drugs in basic medium.
 Formulation: The formulation process involves the addition of certain excipients, which are inactive substances that augment the properties of the drugs. Despite being inactive, these substances can influence drug bioavailability.
 Concentration: According to Fick’s law of diffusion, higher drug concentration in a tissue microenvironment, leads to higher flux through the membrane, resulting in a high rate of absorption.
 Dosage Forms: Drugs can be administered into the body via a number of routes, such as oral, transdermal, ocular and intramuscular. However, it is important to note that the mode of administration plays a very significant role in drug bioavailability. Several studies have demonstrated that only intravenous injections offer 100% drug availability in systemic circulation compared to any other route.
 Physical Forms: The physical form of the drug (solid, liquid or inhalable powder) also affects its rate of absorption. It is worth highlighting that drugs get more absorbed in gaseous form followed by liquid and solid form respectively.

 Chemical Nature: The chemical make-up of a drug is also an important determinant of its absorption potential and bioavailability. It has been observed that inorganic salts are more readily absorbed than organic compounds, when administered via the oral route.

Further, given the rapid increase in the number of NCEs with low solubility and considering that this trend persists in the future as well, there is likely to be a surge in the demand for technologies that facilitate bioavailability enhancement. There are a number of technologies which are already available for improving drug bioavailability. Broadly these technologies can be distributed across three main categories, namely physical, chemical and biological approaches. However, as pharmacological interventions gradually become more complex and novel drug classes are introduced, further innovation may be required in the development of ****ter bioavailability enhancement techniques / methods.

For additional details, please visit
https://www.rootsanalysis.com/....reports/view_documen or email sales@rootsanalysis.com

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About Roots Analysis
Roots Analysis is a global leader in the pharma / biotech market research. Having worked with over 750 clients worldwide, including Fortune 500 companies, start-ups, academia, venture capitalists and strategic investors for more than a decade, we offer a highly analytical / data-driven perspective to a network of over 450,000 senior industry stakeholders looking for credible market insights.

Contact:
Ben Johnson
+1 (415) 800 3415
Ben.johnson@rootsanalysis.com

 

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Request Sample - Bioavailability Enhancement Technologies and Services | Market Size | 2035

The space of bioavailability enhancement technologies and services, driven by the increase in number of BCS II and BCS IV molecules in early phases of development, is likely to grow at CAGR of ~11%, till 2035

Các công ty có dịch vụ tuyển dụng trọn gói là nơi có các chuyên gia chuyên về chiến lược thu hút nhân tài cho các công ty lớn và nhỏ. Vai trò chính của một headhunter là tìm người phù hợp cho những vị trí nhất định. Bài viết sau đây sẽ giới thiệu đến bạn các công ty headhunter tại Việt Nam và những gợi ý lựa chọn hiệu quả.

1. Tại sao cần hợp tác với công ty có dịch vụ tuyển dụng trọn gói?
Khi bộ phận nhân sự làm việc với các nhà tuyển dụng trọn gói, họ sẽ mang lại những lợi ích sau đây cho công ty:
Dịch vụ tận tâm
Các công ty headhunter thường làm việc trực tiếp cho một tập đoàn hoặc làm việc theo hợp đồng để đảm bảo đáp ứng nhu cầu tuyển dụng của họ. Bằng cách này, mọi nỗ lực của họ chỉ dành riêng cho việc tuyển dụng vị trí chiến lược cho công ty thay vì sự chú ý bị phân chia giữa các ứng viên, công việc và ngành.
Quy trình được xác định rõ ràng
Khi làm việc với một công ty headhunter, điều quan trọng là tổ chức và xác định các phương thức tuyển dụng để đảm bảo những người có liên quan đều biết nhiệm vụ và trách nhiệm dẫn đến hiệu quả cao hơn.
Chia sẻ chiến lược và dữ liệu tuyển dụng
Khi các bộ phận nhân sự và công ty headhunter làm việc với nhau, họ sẽ chia sẻ chiến lược tuyển dụng đã được chắt lọc và dữ liệu từ thị trường. Điều này cho phép cả hai cùng phát triển và học hỏi lẫn nhau.
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Các doanh nghiệp tiết kiệm thời gian, tiền bạc và nguồn lực và có thể tìm được những ứng viên thích hợp nhất.
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Các chuyên gia headhunter có thể truy cập vào các nguồn tài nguyên như cơ sở dữ liệu về ứng viên, network công việc và network cá nhân, tăng hiệu suất và hiệu quả trong việc tìm đúng vị trí đang tuyển dụng.
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2. Tiêu chí lựa chọn các công ty tuyển dụng trọn gói hiệu quả
Kinh nghiệm trong ngành
Một headhunter giỏi khi họ có kinh nghiệm và hiểu biết nhất định trong lĩnh vực mà bạn đang cần tuyển dụng. Bằng cách này, họ hiểu những hoạt động như thế nào và có thể lấp đầy vị trí tốt hơn.
Khách hàng tương tự
Công ty headhunter lớn sẽ có thể hiển thị danh mục khách hàng tương tự như về những thứ như ngành, quy mô, doanh thu …. Đặc biệt là về ngành và lĩnh vực kinh doanh! Nguồn tài nguyên của các công ty headhunter tuy không quá rộng nhưng đúng mục tiêu để giúp bạn tìm ra nhân tài phù hợp nhất!
Nhiều tài nguyên
Headhunter phải có quyền truy cập vào những nguồn ứng viên bên ngoài và công nghệ tuyển dụng nền tảng khác để hỗ trợ tìm kiếm.
3. Danh sách các công ty tuyển dụng trọn gói tại Việt Nam hiện nay
Dưới đây là các danh sách những công ty đang hoạt động trong lĩnh vực dịch vụ Headhunter của Việt Nam! Bên cạnh những dịch vụ chuyên Headhunter, còn cung cấp các dịch vụ khác liên quan đế quản lý nhân sự và vận hành công ty!
- HRchannels
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>>> Tham khảo thêm: Việc làm cấp cao
------------------------------------
HRchannels - Headhunter - Dịch vụ tuyển dụng cao cấp
Hotline: 08. 3636. 1080
Email: sales@hrchannels.com / job@hrchannels.com
Địa chỉ: Tòa MD Complex, 68 Nguyễn Cơ Thạch, Nam Từ Liêm, Hà Nội, Việt Nam

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Remote Server Monitoring: How It Works And What You Need To Know

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Remote Server Monitoring: How It Works And What You Need To Know

As you likely know, remote server monitoring has become a fundamental tool for businesses of all sizes and industries. The question is, how ...