Solid­ Phase Peptide Synthesis Approach to long and Cyclic Peptide Synthesis

For example, dipeptide repeats have been implicated in a number of disorders.  We have successfully prepared many long to very long direpeats, including proline-containing poly(Pro-lys)20 that have been associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

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