Malegra enhances the body’s natural erectile response. During sexual stimulation, nitric oxide is released in the penile tissues, which increases cyclic guanosine monophosphate (cGMP). cGMP relaxes smooth muscles and dilates blood vessels in the penis, enabling blood to fill the erectile tissues. Sildenafil inhibits PDE5, the enzyme that breaks down cGMP, helping sustain a strong erection. Sexual arousal is required for effectiveness.

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