Malegra 120 mg works by blocking the PDE5 enzyme, which normally breaks down cyclic guanosine monophosphate (cGMP). When this enzyme is inhibited, cGMP levels increase, causing relaxation of smooth muscles in penile blood vessels. This allows more blood to flow into the erectile tissue during sexual arousal. However, sexual stimulation is still required for the medication to work. Malegra 120 mg should not be taken with nitrate medications or certain heart drugs due to the risk of a dangerous drop in blood pressure. Alcohol and heavy meals may also reduce effectiveness or increase side effects.

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